Barnstable

With nearly 50,000 year-round residents, Barnstable is the largest town on the Cape. It's also the second oldest, founded in 1639. You can get a feeling for its age in Barnstable Village, on and near Main Street (Route 6A), a lovely area of large old homes.

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Fodor's New England: with the Best Fall Foliage Drives, Scenic Road Trips, and Acadia National Park

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