Greyhound serves San Francisco with buses from many major U.S. cities; within California, service is limited to hub towns and cities only. The Greyhound depot is located at the Salesforce Transit Center, in the SoMa district. Tickets can be purchased online; seating is on a first-come, first-served basis. Cash, checks, and credit cards are accepted.

Trending Stories


Find a Hotel


Fodor's San Francisco

View Details