Car Travel
Driving is the best way to get around. The four-lane A6 expressway links the area with central Spain; it takes about 6½ hours to cover the 650 km (403 miles) from Madrid to Santiago, and from Madrid, it's 240 km (149 miles) on the N1 or the A1 toll road to Burgos, after which you can take the N623 to complete the 162 km (100 miles) to Santander.
The expressway north from León to Oviedo and Gijón is the fastest way to cross the Cantabrian Mountains. The AP9 north–south Galician ("Atlantic") expressway links A Coruña, Santiago, Pontevedra, and Vigo, and the A8 in Asturias links Santander to Luarca and beyond. Local roads along the coast or through the hills are more scenic but slower.